Group XVI - Proteoglycans

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

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SIGNAL SEQUENCE

 

   

Human FREM1                      MNSLSWGAANAVLLLLLLAWA

 

Mouse FREM1                      MHSPGCTGPKAQWFLLLQLLLLHLDRVSA

 

 

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CSPG

 

Human FREM1 (CSPG1)  YKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHDEVELEVYDFFF    

Mouse FREM1 (CSPG1)  YKSESAWLPVYIRVGIPNQVPRAAFMAMFVLEVDQFILTPLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQVAYQPPNSSHPERRHYTMELEVYDFFF

 

 

 

 

Human FREM1 (CSPG2)  ERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDG    

Mouse FREM1 (CSPG2)  ERSAPITVHISIRTADTNAPRVSWNTGLNLLEGQSRAITWEQFQIVDNDDIGAVQLVTIGGLQHGRLTVREGKGFLFTVTDLQAGVVRYHHDDSDTTKDFVAFRIFDG

                      

 

 

 

Human FREM1 (CSPG3)  HHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPP     

Mouse FREM1 (CSPG3)  HHSSHHKFPINILPKDDSPPFLITNVVIELEEGKTILIQGSMLRASDMDSSDDYIFFNITKFPQAGEIMKKPGPRLIGYPVPGFLQRDLFSGIIYYRHFGGEIFEDSFEFVLWDSHEPP

                       

 

 

Human FREM1 (CSPG4)  NLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQ

Mouse FREM1 (CSPG4)  NLSVPQVVTIHITPVDDQLPKEAPGISRHLVVKETEVAYITKKHLHFLDMESRDGELIYTVTRPPCFSFSHRHLDAGKLFMVDSIPKLTKNPTAPGLSSFTQ

 

 

 

Human FREM1 (CSPG4)  -------------------HAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHG                              

Mouse FREM1 (CSPG4)  GLILISANQHTCSSQFASQHAVNHMKVAYMPPMQDIGPSPRHVQFTVSVSNQHG

 

 

 

Human FREM1 (CSPG5)  GTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTEHILISDADTKLDNIDLSLRELPLHGR     

Mouse FREM1 (CSPG5)  GALHGICFNITVLPVDNQVPEVFTNTLRVVEGGQCTISTEHILVSDVDTPLDSISLSLKERPLHGG

 

Human FREM1 (CSPG5)  VELNGFPLNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDG      

Mouse FREM1 (CSPG5)  VELDGFPLNPRGTFSWRDLNTLKVWYQHDGSEVLQDEIFLEVTDG                       

                       

 

 

Human FREM1 (CSPG6)  TNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGV      

Mouse FREM1 (CSPG6)  TNSAAFVLHIEVFPVNDEPPILKADLIPMMHCSEGGEVTITPEYISATDADSDDLELLFLIAREPQHGVVRKAGL

                       

Human FREM1 (CSPG6)  TVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLH      

Mouse FREM1 (CSPG6)  HVDRFSQGDVISGAVTYKHTGGEIGLEPCSDTVVLVVSDGEADPLMNGCCYDGPDSSVPLH                       

 

 

 

Human FREM1 (CSPG7)  ASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSV       

Mouse FREM1 (CSPG7)  KSFPTYQLNITVHPVDNQPPSIIIGRMLTVDEGFSAALTTHHLTVVDWDTAPDDLKFMLASQPQFGYLENALPSA

                     

Human FREM1 (CSPG7)  GFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGK       

Mouse FREM1 (CSPG7)  GFEKSNIGIRIASFQWTDMKASHINYVQSRHLRVEPTADQFTVYATDGK                     

 

 

 

Human FREM1 (CSPG8)  HHSLEIPFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQP     

Mouse FREM1 (CSPG8)  HRSLETTFHVIINPTNDEAPDLAVQNITVYEGHMVELDSSIISATDRDIPKDPLLFSIALKPQHGLLVDAAISKDSHQIKQL

                      

Human FREM1 (CSPG8)  ANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDG      

Mouse FREM1 (CSPG8)  ------QHEIHSFSVDLLKNGMKLVYAHDDSESSADNFVIQLSDG                       

 

 

 

Human FREM1 (CSPG9)  KHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQNGQLQLKIGR       

Mouse FREM1 (CSPG9)  KHKILKTISVNITPVNDETPTLSKKAEISMAVGDTRVLSSAVLSATDKDSPREKIHYVFERLPQNGQLQLKIGR

                       

Human FREM1 (CSPG9)  DWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGN       

Mouse FREM1 (CSPG9)  DWVPLSTGMQCTQEDVDLNLLRYTHAGKTDSQDGDSFTFYLWDED                       

 

 

 

Human FREM1 (CSPG10  NRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHYPGVPIT       

Mouse FREM1 (CSPG10) NRSPAFDCHIIIEDMGKGDIVIHAKPLVVVKGDRGLLTTATLLAVDGADKPEELLYLITSPPRHGQVEYVHSPGVPIA

                      

Human FREM1 (CSPG10  NFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNG       

Mouse FREM1 (CSPG10) SFSQMDIAGQTVCYIHKSRTAVPTDSFRFTISNG

 

 

 

Human FREM1 (CSPG11) LRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQ      

Mouse FREM1 (CSPG11) LQTQRGVFEITLQTVDSALPVLTKNKRLRLAEGAMGLLSADHLQLTDPDTPPENLTFFLAQLPRHGYLFLRGK-ALQHNFTQR

                       

Human FREM1 (CSPG11) DVDSKNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGR      

Mouse FREM1 (CSPG11) DVDSGGVAYQHSGGGAREDYFTFLATDRKNQGFVVDGK                       

 

 

 

Human FREM1 (CSPG12) VWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHE

Mouse FREM1 (CSPG12) VQKEPVRFTIQVDQLDKAAPRITHLHSPTQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILRGPLYGRLENTTTGEFIHE

                               

Human FREM1 (CSPG12) KFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGN

Mouse FREM1 (CSPG12) RFSQKDLSHKTILYIINPSLQVTSDILEFQAMDPTGN   

 

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CALX-BETA DOMAIN

Human FREM1         ATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILN

CTLD

Human FREM1                     KSCPAGWHQHSGYCHILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPVAFTN

Mouse FREM1                     RSCPGGWLLHSGYCHILVTRQKGTWTTATRACREQHQGDLVTVLSRRHMQWLWAMSGRKPFWIGLKNQPRTGHWEWIGGEPVAFTN

 

   

Human FREM1                     GRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL

Mouse FREM1                     WRRGAPLHPKPGKNCALVQKRGQWQTKNCSKGKAHNFVCSRKL

 

CONSERVED CORE RESIDUES

 

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This page last updated:	Wednesday, 01 January 2014	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk